I use 2-Bromophenylboronic acid, CAS 244205-40-1, as a practical building block for the preparation of substituted biaryl and aromatic compounds, especially where a bromine substituent and a boronic acid group provide complementary opportunities for further synthesis. Its principal value is the combination of an aryl boronic acid functional group with an ortho-bromine atom on the same benzene ring. For purchasing decisions, I recommend evaluating not only identity and purity, but also packaging, analytical documentation, storage conditions, and the supplier’s ability to support repeat orders.
This guide explains the compound’s basic properties, common synthetic uses, material considerations, buyer selection criteria, and supplier questions. Because physical data can vary with analytical method, hydration state, lot history, and specification, I treat supplier documentation such as a current certificate of analysis and safety data sheet as the controlling reference for a specific batch.
This guide is intended for medicinal chemistry teams, process development groups, academic laboratories, custom synthesis companies, and procurement professionals sourcing organic boronic acids. It is also useful for buyers comparing laboratory-scale material with larger quantities for route development or commercial manufacturing. I focus on practical purchasing and application considerations rather than presenting one fixed specification as universally applicable.
2-Bromophenylboronic acid is an ortho-brominated aryl boronic acid. Its CAS Registry Number is 244205-40-1, and its commonly assigned molecular formula is C6H6BBrO2, with a calculated molecular weight of approximately 200.83 g/mol. The boronic acid group can participate in palladium-catalyzed cross-coupling chemistry, while the aryl bromide can provide a second functionalization handle under suitable reaction conditions.
The adjacent position of these two groups creates useful flexibility for multi-step synthesis. In a carefully designed route, one functional group may be selectively transformed before the other, although actual selectivity depends on the catalyst, base, solvent, temperature, substrate concentration, and reaction sequence. I therefore recommend confirming compatibility through literature review, small-scale experimentation, or process-development testing rather than assuming that every reported transformation will transfer directly.
| Parameter | Typical reference information | Buyer consideration |
|---|---|---|
| Product | 2-Bromophenylboronic acid | Confirm the exact positional isomer |
| CAS number | 244205-40-1 | Match the CAS number across quotation, label, COA, and SDS |
| Molecular formula | C6H6BBrO2 | Check consistency with analytical documentation |
| Calculated molecular weight | Approximately 200.83 g/mol | Use the supplier’s stated value for ordering and formulation records |
| Functional groups | Aryl boronic acid and aryl bromide | Assess both groups when planning reaction sequences |
The material is generally supplied as a solid, but appearance alone is not sufficient for release or acceptance. Color, particle form, and flow behavior can differ between lots without necessarily proving a change in chemical identity. For controlled purchasing, I suggest requesting the current lot-specific appearance, assay method, water content where relevant, and impurity profile.
Solubility and stability should be considered operationally rather than treated as fixed universal values. Many aryl boronic acids show limited solubility in water and better compatibility with selected organic solvents, but the practical result depends on concentration, temperature, pH, and solvent grade. A buyer should request handling recommendations from the supplier and verify dissolution behavior in the intended reaction solvent before committing to a larger batch.
The most recognizable use of 2-Bromophenylboronic acid is as an aryl boronic acid partner in Suzuki-type cross-coupling reactions. Under an appropriate catalytic system, the boronic acid group can react with an aryl or heteroaryl halide to form a carbon-carbon bond. This makes the compound relevant to the preparation of biaryl intermediates used in pharmaceutical research, agrochemical discovery, electronic materials development, and fine chemical synthesis.
Because the molecule also contains an aryl bromide, it can support sequential or convergent synthetic planning. A chemist may use the boronic acid group in one step and preserve, or deliberately transform, the bromine-bearing position in a later step. The feasibility of this approach must be confirmed experimentally because competing coupling, protodeboronation, steric effects, and catalyst sensitivity can influence yield and selectivity.
In medicinal chemistry, this building block can help create small libraries of substituted aromatic compounds. Its two reactive handles may reduce the need to redesign a core structure when different substituents are required during structure-activity relationship studies. In process chemistry, the key question is not only whether the reaction works, but whether the material can be supplied consistently with suitable impurity control, packaging, and documentation.
Academic and contract research laboratories may use this compound in route scouting, intermediate preparation, and method-development work. For these applications, smaller packages and flexible delivery can be more important than a long-term supply agreement. For scale-up, the buyer should transition from a catalog-style assessment to a technical review covering batch size, analytical method transfer, retest period, storage, and change-control communication.
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I recommend selecting a purity level according to the application rather than paying automatically for the highest nominal grade. A discovery project may begin with a research-grade specification, while a regulated or highly sensitive route may require tighter controls on related substances, residual solvents, metals, and water. The supplier should identify the test methods used, such as HPLC, GC, NMR, titration, or elemental analysis, and explain which results are reported on the COA.
Do not rely on a single assay number as the complete quality assessment. For boronic acids, the buyer may also need to consider degradation-related impurities, inorganic residues, residual solvents, and lot-to-lot appearance. I suggest requesting a representative COA before purchase and a lot-specific COA before release whenever the project has strict quality requirements.
Packaging should protect the product from contamination, moisture exposure, and repeated handling. The appropriate container depends on quantity, transport conditions, and the supplier’s stability assessment. Buyers should follow the product SDS and label instructions, keep the container tightly closed, and use suitable laboratory personal protective equipment during handling.
Storage conditions should be confirmed for the exact product and package size. I avoid presenting one universal temperature or shelf-life claim because these values require product-specific stability support. If a project will hold inventory for several months, I recommend discussing retest dates, recommended storage, reserve samples, and the supplier’s procedure for investigating an out-of-specification result.
Pricing for 2-Bromophenylboronic acid usually depends on purity, package size, production route, analytical requirements, stock status, and shipping destination. A small research pack and a kilogram-scale quotation are not directly comparable because their packaging, testing, labor, and logistics structures differ. I advise buyers to request pricing at the actual quantities needed for development, validation, and routine production.
Minimum order quantity and lead time should be confirmed in writing. Stocked material may support faster dispatch, while made-to-order material may require additional production and testing time. A practical request should state the required quantity, target delivery date, destination, documentation needs, packaging preference, and whether a pre-shipment sample or approval sample is required.
I also recommend evaluating communication quality before placing a large order. A responsive supplier should distinguish confirmed data from estimates and should not present unverified purity, delivery, or stability claims as guaranteed outcomes. Clear answers about documentation and batch availability often provide a more useful sourcing signal than a low initial price alone.
At Maison Chemical, we support buyers seeking 2-Bromophenylboronic acid CAS 244205-40-1 for research, custom synthesis, and process-development applications. We can discuss required quantity, target specification, packaging, documentation, and delivery destination before preparing a quotation. Our approach is to align the proposed material and service level with the buyer’s actual use rather than applying the same recommendation to every project.
For a technical inquiry, I recommend sending your required quantity, purity expectation, application stage, preferred delivery schedule, and any COA or packaging requirements. This information helps us assess availability and provide a more relevant commercial response. Where the application is sensitive to water, trace metals, or specific impurities, those requirements should be stated at the beginning of the inquiry.
2-Bromophenylboronic acid CAS 244205-40-1 is a versatile synthetic intermediate when a project benefits from both boronic acid and bromine functionality on an aromatic ring. Its suitability depends on the planned reaction sequence, impurity tolerance, handling conditions, and supply requirements. I recommend beginning with a clear technical specification and verifying the supplier’s current lot documentation before moving from laboratory evaluation to larger-scale purchasing.
If you are sourcing this compound, send Maison Chemical your required quantity, target purity, delivery location, packaging preference, and documentation needs. We can then review the request and provide availability, commercial terms, and suitable supplier support for your project stage.
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