4-tert-Butoxyphenyl boronic acid, CAS 176672-49-4, is an aryl boronic acid used mainly as a coupling partner in organic synthesis. I identify this material by its para-tert-butoxy-substituted phenyl group and boronic acid functionality, which supports carbon–carbon bond formation in Suzuki–Miyaura reactions. Its commonly reported molecular formula is C10H15BO3, with a molecular weight of approximately 194.04 g/mol.
This compound is most relevant to pharmaceutical, agrochemical, specialty chemical, and advanced-materials research teams that need a functionalized aryl building block. When buying it, I recommend confirming the exact CAS number, assay requirement, water content, appearance, packaging, and batch documentation before placing an order. Maison Chemical can support commercial inquiries by reviewing the required specification, quantity, application, and delivery destination.
I prepared this guide for procurement specialists, process chemists, medicinal chemistry teams, R&D laboratories, and distributors sourcing 4-tert-butoxyphenyl boronic acid. It is also useful for buyers comparing laboratory quantities with larger project-based supply. The goal is to connect chemical identity with practical purchasing decisions rather than treating the CAS number as the only selection criterion.
This material may be ordered for route scouting, parallel synthesis, scale-up development, or use as a specialty intermediate. Each application can require a different balance between purity, packaging, delivery time, and documentation. For that reason, I recommend defining the intended reaction and scale before requesting a quotation.
4-tert-Butoxyphenyl boronic acid contains two important structural features: an aryl boronic acid group and a tert-butoxy substituent positioned on the aromatic ring. The boronic acid group is the principal reactive handle, while the tert-butoxy group modifies the electronic and steric character of the aryl building block. This combination makes the compound useful when a synthesis requires a protected or oxygen-containing aryl fragment.
| Property | Buying-Relevant Information |
|---|---|
| Common name | 4-tert-Butoxyphenyl boronic acid |
| CAS number | 176672-49-4 |
| Molecular formula | C10H15BO3 |
| Approximate molecular weight | 194.04 g/mol |
| Functional class | Aryl boronic acid and oxygen-containing aromatic intermediate |
The material is generally handled as a solid chemical intermediate, but its exact appearance, particle form, and stability should be confirmed from the supplier’s current batch specification. Boronic acids can be sensitive to moisture and may participate in equilibria involving boronic acid, boronate, and related forms depending on the solvent and conditions. I therefore recommend using the supplied safety data sheet and certificate of analysis for storage and handling decisions.
The most direct application is use as an aryl donor in Suzuki–Miyaura cross-coupling. In this reaction family, the aryl boronic acid can react with an appropriate aryl or vinyl halide under a suitable palladium catalyst and base system. The result is typically a biaryl or related carbon–carbon coupled product, although the actual conversion depends on the reaction partners and process conditions.
This building block can be useful when a target molecule requires a para-tert-butoxyphenyl fragment. I recommend confirming compatibility with the selected catalyst, base, solvent, temperature, and work-up procedure at laboratory scale before planning a larger purchase. A small qualification batch can help identify issues such as protodeboronation, incomplete conversion, or difficult purification.
Medicinal chemistry teams may use this compound to introduce a substituted aromatic unit into screening molecules or route intermediates. Its value is mainly structural: it provides a defined aryl boronic acid handle for library synthesis and analogue preparation. It should not be treated as an active pharmaceutical ingredient or as evidence of biological performance without product-specific testing.
Research groups developing crop-protection compounds, functional additives, or other specialty molecules may also evaluate this intermediate. The suitability depends on the final molecular design and the required impurity profile. I advise buyers to discuss downstream restrictions, residual solvent limits, and analytical methods with the supplier before moving from research use to process development.
For this product, “type” usually refers less to a different chemical form and more to the supply format and quality level. Common purchasing options may include research-scale material, development-scale material, and larger commercial quantities, subject to manufacturing capability and available stock. Buyers should avoid assuming that different pack sizes have identical documentation or lead times without confirmation.
Key specifications to request include assay, water content, residual solvents, related substances, appearance, and analytical method. Depending on the project, buyers may also request NMR, HPLC, GC, LC–MS, or other analytical data, but the relevant method should match the compound’s physical and chemical behavior. I recommend asking whether the reported assay is measured on an as-is basis or corrected for water and other volatile components.
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Start by confirming the complete name, CAS 176672-49-4, molecular formula, and intended structure. Similar aryl boronic acids may have different substituent positions or different alkoxy groups, so a name-only search can create avoidable errors. I recommend checking the supplier quotation, product label, certificate of analysis, and shipment documents for consistency.
Next, define whether the material is for exploratory chemistry, route development, or a controlled manufacturing process. A discovery project may prioritize fast availability and a practical assay specification, while a process project may require tighter impurity controls and lot-to-lot consistency. The correct requirement should be based on the downstream reaction and purification strategy rather than on a generic “high purity” description.
Estimate consumption from the reaction plan, expected yield, repeat experiments, and contingency needs. For example, a laboratory may begin with a 1 g or 5 g evaluation quantity, while a development program may request 100 g or more, depending on the route. These quantities are examples for planning only; actual MOQ, packaging, and availability should be confirmed with Maison Chemical for the specific project.
Before purchase, request the current certificate of analysis, safety data sheet, product specification, packaging details, and expected lead time. I also recommend confirming whether the material is supplied from available inventory or scheduled production. Import requirements, dangerous-goods classification, temperature limitations, and local customs procedures can affect the practical delivery schedule.
The price of 4-tert-butoxyphenyl boronic acid can vary according to quantity, purity, analytical requirements, packaging, production route, and destination. A larger quantity may improve the unit economics, but it can also involve a higher minimum order and a longer manufacturing schedule. I recommend comparing total delivered cost rather than comparing the material price alone.
Lead time should be treated as a project variable rather than a fixed product characteristic. Stock availability can support faster dispatch, while custom production or additional quality testing may require more time. When requesting a quotation, provide the required quantity, target delivery date, destination country, packaging preference, and documentation requirements so the supplier can offer a realistic response.
I use the following checklist when evaluating a chemical supplier for this type of intermediate. It focuses on evidence that can be reviewed before commitment rather than on unsupported claims about performance or market position.
Maison Chemical supports B2B inquiries for organic boronic acids by reviewing the buyer’s technical and commercial requirements. We can discuss the intended application, quantity range, target specification, packaging, and destination before preparing a quotation. Where project details are incomplete, I recommend beginning with a specification review so that the proposed supply option is aligned with the actual synthesis plan.
One common mistake is ordering by a shortened product name without confirming the CAS number and substitution position. Another is assuming that a stated assay alone guarantees performance in every coupling system, because reaction outcome also depends on the reaction partner, catalyst, base, solvent, and purification process. Buyers should also avoid treating a small laboratory pack as proof that the same material is immediately available at production scale.
Storage is another important consideration. The product should be handled according to the supplier’s safety data sheet and label, with attention to moisture exposure, container closure, and local chemical-handling requirements. If the compound will remain in inventory for an extended period, I recommend discussing retest policy and recommended storage conditions before purchase.
4-tert-Butoxyphenyl boronic acid CAS 176672-49-4 is a functionalized aryl boronic acid with a reported molecular weight of approximately 194.04 g/mol. Its principal value is as a building block for Suzuki–Miyaura coupling and related organic synthesis, particularly when a para-tert-butoxyphenyl group is required. The best purchasing decision depends on verified identity, application-appropriate purity, documentation, quantity, packaging, and delivery requirements.
For the next step, I recommend preparing a concise inquiry that includes the CAS number, required quantity, target assay, intended use, packaging preference, destination, and requested documents. Maison Chemical can then review the specification and advise on a suitable supply route, MOQ, lead time, and commercial offer. This approach helps reduce identity errors, improve quotation accuracy, and support a more reliable transition from laboratory evaluation to project supply.
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