2,4-Difluorophenylboronic acid, identified by CAS No. 144025-03-6, is an aromatic boronic acid used primarily as a building block in organic synthesis. Its molecular formula is C6H5BF2O2, and its calculated molecular weight is approximately 157.93 g/mol. The molecule contains a phenyl ring substituted with fluorine atoms at the 2- and 4-positions and a boronic acid group that can participate in palladium-catalyzed cross-coupling reactions. I supply this material for research, process development, and commercial synthesis subject to agreed specifications, documentation, packaging, and quantity requirements.
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Because product appearance, assay, water content, residual solvents, and impurity limits can vary by manufacturing route and grade, buyers should confirm the current specification and certificate of analysis before placing an order. Public chemical databases are useful for identity confirmation, but they do not replace a lot-specific quality document. PubChem lists the compound identity and chemical structure information associated with CAS 144025-03-6. [Source: U.S. National Library of Medicine, PubChem, “2,4-Difluorophenylboronic acid,” accessed for identity reference.]
2,4-Difluorophenylboronic acid belongs to the class of aryl boronic acids, which are widely used in medicinal chemistry, pharmaceutical intermediate synthesis, agrochemical research, and advanced organic synthesis. The boronic acid functionality is the principal reactive handle, while the two fluorine substituents modify the electronic and lipophilic properties of the aromatic ring. This combination allows chemists to introduce a 2,4-difluorophenyl group into more complex molecular structures.
In a typical Suzuki–Miyaura coupling, the aryl boronic acid reacts with an appropriate aryl or vinyl halide in the presence of a suitable palladium catalyst, base, solvent system, and controlled reaction conditions. The exact conversion depends on the coupling partner, catalyst system, substrate concentration, temperature, reaction time, and work-up procedure. I therefore recommend treating this material as a synthesis intermediate rather than assuming that one universal process condition will apply to every project.
| Parameter | Information |
|---|---|
| Common name | 2,4-Difluorophenylboronic acid |
| CAS Registry Number | 144025-03-6 |
| Molecular formula | C6H5BF2O2 |
| Calculated molecular weight | Approximately 157.93 g/mol |
| Fluorine substitution | Two fluorine atoms at the 2- and 4-positions |
| Functional group | Aryl boronic acid |
Based on the anhydrous molecular formula and standard atomic weights, the approximate elemental composition is 45.62% carbon, 3.19% hydrogen, 6.83% boron, 24.06% fluorine, and 20.30% oxygen by mass. These calculated percentages are theoretical values and should not be confused with an analytical assay or release specification. For purchasing and manufacturing control, I use the lot-specific certificate of analysis rather than relying only on calculated composition.
The compound is generally handled as a solid organic intermediate, although the exact color, particle form, and physical behavior may differ between lots and packaging formats. Its boronic acid group is sensitive to the surrounding chemical environment and may participate in reversible interactions with diols, water, and other nucleophilic species. Buyers should consult the current safety data sheet for verified information on stability, incompatibilities, exposure controls, and disposal.
The two fluorine atoms influence the electronics of the aromatic ring and can affect reaction behavior compared with unsubstituted phenylboronic acid or other fluorinated analogues. However, fluorine substitution does not guarantee higher yield, faster reaction, or improved stability in every synthetic system. Reaction screening remains appropriate when the material is introduced into a new route.
I recommend storing the material in a tightly closed, clearly labeled container under the conditions specified in the applicable SDS and product specification. Moisture exposure, repeated opening, heat, contamination, and prolonged contact with incompatible reagents should be minimized. A receiving laboratory should inspect the package, verify the lot number, review the SDS, and check the material against its certificate of analysis before use.
For routine handling, buyers should use suitable laboratory or plant controls, including protective gloves, eye protection, local ventilation, and procedures appropriate to the full formulation and scale. The correct control measures depend on the quantity, powder characteristics, process equipment, and other substances present. The Globally Harmonized System provides the internationally recognized framework for communicating chemical hazards through labels and safety data sheets. [Source: United Nations, Globally Harmonized System of Classification and Labelling of Chemicals, current applicable edition.]
The most important use of 2,4-difluorophenylboronic acid is as an aryl donor in carbon–carbon bond-forming reactions. It can be evaluated for coupling with aryl halides, heteroaryl halides, and selected vinyl electrophiles to produce biaryl or substituted alkene structures. The reaction is commonly developed with a palladium catalyst and a base, but catalyst loading, solvent, temperature, atmosphere, and purification must be optimized for each substrate.
For route development, I suggest screening a small set of conditions rather than selecting a catalyst system solely from the boronic acid name. Important variables include the electrophile class, steric hindrance near the coupling site, boronic acid stability, base strength, water content, and the risk of protodeboronation. Analytical monitoring by an appropriate method, such as HPLC, LC–MS, GC, or NMR, should be selected according to the product and impurity profile.
Fluorinated aryl fragments are frequently investigated in medicinal chemistry because fluorine can influence molecular size, polarity, metabolic behavior, and conformational or electronic properties. 2,4-Difluorophenylboronic acid provides a practical route for incorporating a defined difluorinated aromatic unit into screening compounds and intermediate structures. Its suitability depends on the target structure, downstream functional-group tolerance, and the required purity level.
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This material may be useful during discovery, process research, and intermediate preparation, but it should not be described as an active pharmaceutical ingredient. Any pharmaceutical or regulated application requires project-specific qualification, impurity assessment, traceability, and documented manufacturing controls. I can support this evaluation by discussing intended use, batch size, analytical requirements, and documentation expectations before quotation.
The same coupling reactivity can support the preparation of fluorinated specialty molecules and research intermediates for crop-protection, materials, and performance-chemical programs. Commercial value is usually determined by more than nominal purity: reproducibility, impurity control, packaging, delivery schedule, and technical communication can be equally important. A material that performs well in a milligram-scale screen may require additional process review before kilogram-scale use.
Buyers may encounter this product in research grade, synthesis grade, or a customer-specific commercial grade. These labels are not interchangeable with a universal legal or technical standard, so I recommend comparing the actual specification rather than relying on the grade name alone. Key differences may include assay method, assay limit, water content, residual solvents, inorganic residue, palladium or other metal residues, particle form, and packaging.
For early discovery work, a small pack with identity confirmation may be sufficient. For process development, buyers generally need a consistent assay method, impurity profile, batch traceability, and sufficient sample quantity for repeat experiments. For manufacturing supply, the purchasing specification should define acceptance criteria, packaging configuration, retest or shelf-life policy where applicable, shipping requirements, and change-notification expectations.
The correct specification starts with the intended reaction and downstream use. A research chemist may prioritize availability and a practical pack size, while a process chemist may prioritize lot consistency, low water content, controlled impurities, and repeat supply. A procurement team should also assess whether the supplier can provide pre-shipment documents, export support, packaging information, and a realistic lead-time estimate.
Assay alone is not always enough to predict process performance. Trace metals, residual solvents, water, particle characteristics, and structurally related impurities can influence catalyst performance or purification. I recommend sharing the target application, approximate annual demand, required delivery region, and documentation requirements so that the quotation can be aligned with the actual project.
Published chemical data should be cross-checked against the project’s quality requirements. The International Council for Harmonisation describes quality principles relevant to pharmaceutical development and manufacturing, including the importance of controlling material attributes that can affect product quality. [Source: ICH Q7, Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients, and ICH Q8(R2), Pharmaceutical Development.] These guidelines do not automatically certify this product, but they provide useful context for buyers establishing a risk-based raw-material qualification process.
At Maison Chemical, I approach 2,4-difluorophenylboronic acid as a sourcing and technical-support requirement rather than only a catalog item. I can help customers confirm identity, compare requested specifications, review available documentation, and coordinate packaging or delivery discussions. The final offer depends on quantity, grade, destination, current production availability, and the level of quality documentation required.
For a new project, I recommend beginning with a specification review and, where appropriate, a sample or small evaluation quantity. For larger programs, I can discuss batch planning, repeat-order expectations, shipment timing, and customer-specific quality requirements. Any statement about purity, lead time, or supply capacity should be confirmed in the formal quotation and supporting documents for the relevant lot.
2,4-Difluorophenylboronic acid CAS 144025-03-6 is an aryl boronic acid intermediate with the formula C6H5BF2O2 and a calculated molecular weight of approximately 157.93 g/mol. Its principal value is its use as a difluorinated aryl building block, especially in Suzuki–Miyaura and related carbon–carbon coupling research. The two fluorine atoms define the substitution pattern, while the boronic acid group provides the key synthetic reactivity.
Before buying, I recommend confirming the current assay, impurity limits, water content, analytical methods, packaging, documentation, and delivery requirements. Send Maison Chemical your target quantity, intended application, destination, and preferred specification, and I can prepare a project-specific sourcing response. This approach helps ensure that the selected material is suitable not only for an initial experiment but also for a controlled and repeatable B2B supply program.
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