3-Fluoro-2-methylbenzeneboronic acid, identified by CAS No. 163517-61-1, is an aromatic boronic acid used primarily as a building block in synthetic organic chemistry. Its structure combines a boronic acid group with a fluorine atom and a methyl substituent on a benzene ring, providing a useful platform for carbon–carbon bond formation and further molecular modification. At Maison Chemical, we supply this compound for research, process development, and custom synthesis applications, subject to project-specific availability and documentation.
The compound is generally represented by the molecular formula C7H8BFO2 and has an approximate molecular weight of 153.95 g/mol. Its most recognized role is as an aryl boronic acid reagent in palladium-catalyzed Suzuki–Miyaura coupling, although the precise reaction conditions must be established for each substrate and process. Buyers should confirm identity, assay, physical form, packaging, and analytical requirements before placing a production order.
3-Fluoro-2-methylbenzeneboronic acid belongs to the family of organic boronic acids, specifically substituted aryl boronic acids. The boronic acid functionality is commonly written as –B(OH)2, and this group can participate in transmetalation during suitable palladium-catalyzed coupling reactions. The fluorine and methyl groups occupy different positions on the aromatic ring, creating a defined substitution pattern that is important for structure–activity studies and route design.
| Property | Information |
|---|---|
| Product name | 3-Fluoro-2-methylbenzeneboronic acid |
| CAS number | 163517-61-1 |
| Molecular formula | C7H8BFO2 |
| Approximate molecular weight | 153.95 g/mol |
| Functional class | Substituted aryl boronic acid |
| Primary chemical role | Cross-coupling and synthetic intermediate |
Like other boronic acids, this material may be sensitive to moisture, storage conditions, and repeated handling. Some boronic acids can undergo oxidation or form aggregates and related species depending on their environment, concentration, and analytical method. For that reason, I advise customers to follow the supplier’s storage instructions and to use an analytical method appropriate for boronic acid intermediates.
The most important synthetic function of 3-fluoro-2-methylbenzeneboronic acid is its use as an aryl partner in Suzuki–Miyaura coupling. In a typical reaction concept, the boronic acid reacts with an aryl or heteroaryl halide in the presence of a suitable palladium catalyst, base, solvent, and controlled reaction conditions. The transformation can generate a biaryl or related carbon–carbon bond, allowing the substituted aromatic ring to be incorporated into a more complex molecule.
Reaction performance depends on the electrophile, catalyst system, base, solvent, temperature, concentration, and work-up procedure. Therefore, I do not recommend treating a published general coupling condition as a guaranteed process specification. A small-scale screen may be appropriate before process transfer, especially when the target molecule contains multiple coordinating groups or sterically demanding substituents.
The fluorine atom provides a defined substitution feature for medicinal chemistry and advanced intermediate design. Fluorinated aromatic fragments are frequently evaluated because fluorine substitution can affect electronic character, lipophilicity, metabolic behavior, and molecular conformation. These effects are molecule-dependent, so the presence of fluorine should be viewed as a design option rather than proof of a specific biological or physical outcome.
The methyl group also contributes to the substitution pattern and may influence steric environment and electronic behavior around the ring. Combining methyl and fluoro substituents with a boronic acid group gives chemists a compact, differentiated intermediate for analogue synthesis. This can be useful when a project requires rapid preparation of structurally related compounds.
In pharmaceutical research, this compound may be selected for preparing biaryl fragments, screening libraries, reference intermediates, or route-development samples. Its value is typically greatest during discovery and process research, where chemists need reliable access to structurally specific building blocks. Final suitability depends on the target structure and the reaction route selected by the development team.
In agrochemical research, substituted aryl boronic acids can be used to construct candidate molecules containing tailored aromatic groups. The same intermediate may also support the preparation of specialty chemicals, electronic-material precursors, and other research compounds. These applications should be evaluated according to project-specific reaction data, downstream specifications, and applicable chemical handling requirements.
Contract research organizations and custom synthesis laboratories may purchase this material for route scouting and parallel synthesis. Universities and industrial laboratories may also use it in gram-scale or smaller experiments. For larger programs, the key question is not only whether the material is available, but whether the supplier can maintain consistent quality and provide suitable batch documentation.
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Research-scale material is generally suitable for feasibility studies, reaction screening, and early-stage medicinal chemistry. Buyers often prioritize prompt availability, practical packaging, and a certificate of analysis that confirms identity and assay. When only a limited quantity is required, a small pack can reduce inventory exposure while the route is still being evaluated.
Process-development projects require more detailed review. In addition to assay, customers may need information about water content, residual solvents, elemental impurities, particle characteristics, and stability under proposed storage conditions. The exact testing panel should be agreed before production, because not every project requires the same analytical limits.
For repeat orders, Maison Chemical can discuss packaging, batch size, documentation, and delivery planning according to the buyer’s requirements. Custom synthesis or specification adjustment may be considered when the standard material does not fully match a project’s needs. Any custom arrangement should be evaluated through a technical discussion, quotation, and documented quality agreement where appropriate.
I recommend beginning with a clear product specification that includes the exact chemical name, CAS number, required quantity, target assay, acceptable impurity profile, packaging format, and intended use. Confirming the CAS number is especially important because positional isomers of substituted benzeneboronic acids can have different synthetic performance and commercial availability. Buyers should also ask whether the quoted material is standard stock, made to order, or subject to a new production schedule.
Documentation is another important selection factor. A practical supplier package may include a certificate of analysis, safety data sheet, product specification, batch information, and shipping documentation, depending on the order and destination. If the material will enter a regulated development workflow, customers should communicate their documentation expectations before purchase rather than after shipment.
Storage and logistics should also be discussed. The product should be stored according to the supplier’s recommended temperature, moisture-control, light-protection, and packaging guidance, with the exact conditions confirmed for the supplied batch. For international orders, I recommend checking import requirements, dangerous-goods classification if applicable, customs documents, and the remaining shelf-life expectation at delivery.
At Maison Chemical, we approach 3-fluoro-2-methylbenzeneboronic acid as a technical sourcing project rather than a simple catalog transaction. I can help customers review the intended application, required quantity, quality expectations, packaging, and delivery destination before a quotation is finalized. This helps reduce avoidable differences between a research-grade request and a process-oriented procurement request.
Our support can include product identification, specification discussion, documentation coordination, export preparation, and supply planning. Availability, MOQ, lead time, and pricing may vary according to batch status, quantity, analytical requirements, and destination. Because these conditions are project-specific, I recommend requesting a current quotation instead of relying on an outdated market estimate.
3-Fluoro-2-methylbenzeneboronic acid CAS 163517-61-1 is a defined fluorinated and methyl-substituted aryl boronic acid used mainly as a synthetic intermediate. Its approximate molecular weight is 153.95 g/mol, and its boronic acid group makes it a practical candidate for suitable cross-coupling and analogue-development routes. The compound can support pharmaceutical, agrochemical, medicinal chemistry, and specialty synthesis programs, but actual performance must be confirmed in the customer’s reaction system.
The next step is to send Maison Chemical your required quantity, target specification, application stage, packaging preference, destination, and documentation needs. I can then help clarify availability, MOQ, lead time, and the appropriate supply option. For a dependable purchasing decision, compare the complete technical and logistics package—not only the unit price.
Contact us to discuss your requirements of 3-Fluoro-2-methylbenzeneboronic acid CAS 163517-61-1. Our experienced sales team can help you identify the options that best suit your needs.