3,4-Dichlorophenylboronic acid, CAS 151169-75-4, is an aryl boronic acid used mainly as a coupling intermediate in pharmaceutical, agrochemical, and specialty organic synthesis. I recommend evaluating it as a reaction-grade raw material rather than as a finished active ingredient. Its key buying factors are confirmed identity, assay, impurity profile, moisture control, packaging, documentation, and the supplier’s ability to support the required scale.
At Maison Chemical, I help buyers assess this compound according to their process requirements, including laboratory development, route optimization, pilot production, and repeat manufacturing. The molecular formula is generally represented as C6H5BCl2O2, with a calculated molecular weight of approximately 190.86 g/mol. Because specifications can vary by application and batch, I advise requesting a current technical data sheet, certificate of analysis, and sample before approving a commercial order.
This guide is intended for procurement teams, process chemists, research laboratories, contract manufacturers, and chemical distributors evaluating 3,4-Dichlorophenylboronic acid. It is especially relevant when a project requires a defined aryl boronic acid for carbon–carbon bond formation. The information also helps buyers compare direct material sourcing with alternatives such as the corresponding boronic ester.
I focus here on practical purchasing questions: what the compound does, how it is typically used, which specifications deserve attention, and how to prepare an effective inquiry. I do not treat a general specification as a guarantee for every batch or reaction. The final acceptance criteria should be agreed between the buyer, supplier, and technical team before production use.
3,4-Dichlorophenylboronic acid contains an aryl boronic acid functional group and two chlorine substituents on the phenyl ring. The boronic acid group can participate in palladium-catalyzed Suzuki–Miyaura coupling with suitable aryl or vinyl halides. This makes the material useful for constructing biaryl and substituted aromatic structures in medicinal chemistry and intermediate synthesis.
The two chlorine atoms are not simply passive identifiers; they influence the electronic and steric environment of the aromatic ring. Their presence may affect reaction rate, solubility, purification, and the behavior of downstream intermediates. For that reason, I recommend confirming the complete synthetic route rather than selecting the raw material only by its CAS number.
Actual suitability depends on the reaction system, catalyst, base, solvent, temperature, concentration, and work-up method. I therefore avoid promising universal conversion or yield. A small-scale compatibility test is normally the most reliable way to confirm whether a particular batch meets the project’s reaction needs.
The free boronic acid is not identical to a protected boronic ester such as a pinacol ester. The free acid may be preferred when the route or reaction method is already designed around that form, while an ester can offer different handling or stability characteristics in some workflows. However, changing between forms can affect molecular weight, stoichiometry, solubility, deprotection requirements, and process conditions.
I recommend that buyers specify the exact chemical form, CAS number, molecular formula where applicable, and intended use. This prevents accidental substitution with a related compound that may appear similar in a catalog but behaves differently in synthesis. If a protected form is acceptable, the buyer should state that flexibility explicitly rather than leaving the supplier to make the assumption.
| Specification area | What the buyer should confirm |
|---|---|
| Identity | CAS 151169-75-4, chemical name, formula, molecular weight, and analytical identity data |
| Assay | Test method, reporting basis, and acceptance target agreed for the application |
| Impurities | Related organic impurities, residual starting materials, and route-specific contaminants |
| Physical form | Appearance, color, particle characteristics, and any defined material description |
| Water and solvents | Moisture level and residual solvent limits when these can affect reaction performance |
| Documentation | Certificate of analysis, safety data sheet, packing information, and batch traceability |
A calculated molecular weight of approximately 190.86 g/mol is useful for stoichiometric planning, but it does not replace identity testing. Buyers often compare assay targets such as 98% or higher, yet the correct limit depends on the route, analytical method, and impurity tolerance. I recommend accepting only a specification that includes a defined test method and a clear basis for the reported result.
First, I ask whether the material is intended for discovery screening, process development, pilot production, or commercial manufacturing. These stages can require different levels of batch documentation, packaging control, impurity characterization, and supply continuity. A small research order may prioritize rapid availability, while a production project may require formal change control and repeat-batch consistency.
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Next, review the reaction’s sensitivity to water, catalyst poisons, metals, and organic impurities. If the route uses a low catalyst loading or a difficult purification step, tighter control may be commercially valuable even when a basic assay specification appears acceptable. I suggest sharing the reaction type and critical quality attributes with the supplier so that the proposed specification reflects actual process risk.
Packaging should protect the material from contamination, excessive moisture exposure, and unnecessary opening during storage or dispensing. The supplier should identify the primary container, outer packaging, net quantity, labeling, and batch number. For larger purchases, I also recommend confirming whether the same packaging configuration can be maintained across repeat shipments.
Storage instructions should follow the supplier’s current safety data sheet and product documentation. A buyer should not assume that one storage condition is suitable for every formulation or packaging size. Where the material is sensitive to moisture or prolonged exposure to unsuitable conditions, a controlled, tightly closed storage approach is prudent, subject to the supplier’s technical guidance.
The price of 3,4-Dichlorophenylboronic acid can vary with order quantity, assay requirement, packaging, testing, manufacturing route, and whether the material is available from stock or must be scheduled. There is no responsible universal price or minimum order quantity without a defined grade and quantity. I recommend requesting separate quotations for sample, development, pilot, and recurring commercial volumes.
Lead time should be confirmed in writing because stock status and production scheduling can change. For a time-sensitive project, ask whether the quoted lead time includes quality release, repacking, export documentation, and transport preparation. A lower unit price may not be the best commercial choice if it creates a longer qualification cycle or a higher risk of supply interruption.
For repeat purchasing, I advise checking lot-to-lot consistency, retention sample policy, change notification, and the supplier’s ability to provide the same analytical package for future batches. These details are particularly important when the compound is incorporated into a regulated or tightly controlled manufacturing process. A dual-source strategy may also be considered when the material is a critical route input.
Maison Chemical can support buyers by clarifying the requested chemical form, preparing a quotation based on quantity and quality requirements, and coordinating technical documents for evaluation. I can also help organize a sample request before a larger purchase is made. The final quotation and delivery schedule should be confirmed against the buyer’s destination, packaging needs, and applicable shipping requirements.
One common mistake is treating the CAS number as the complete specification. CAS identification is essential, but it does not define every acceptable assay, impurity limit, water content, packaging condition, or analytical method. Another mistake is comparing suppliers only by price without considering documentation, sample support, and continuity of supply.
Buyers should also avoid changing from the free acid to a protected ester without recalculating equivalents and reviewing the reaction procedure. If the material will be used in a sensitive coupling reaction, a representative sample and defined incoming inspection plan can reduce avoidable risk. I recommend recording the approved batch, analytical data, storage conditions, and re-test requirements in the purchasing file.
3,4-Dichlorophenylboronic acid CAS 151169-75-4 is a specialized aryl building block primarily valued for synthetic applications such as Suzuki–Miyaura coupling and related intermediate preparation. The most important purchasing priorities are correct chemical form, verified identity, suitable assay and impurity limits, appropriate packaging, complete documentation, and dependable repeat supply. Its calculated molecular weight is approximately 190.86 g/mol, but buyers should use supplier-provided analytical documentation for final release decisions.
To begin sourcing, prepare the required quantity, target specification, intended application, packaging preference, destination, and requested delivery date. Send these details to Maison Chemical so I can recommend an appropriate supply option and provide the relevant technical and commercial information. A sample evaluation followed by an agreed specification is the practical next step before committing to larger-volume purchasing.
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