4-Bromophenylboronic acid, identified by CAS 5467-74-3, is an aryl boronic acid used primarily as a synthetic building block in modern organic chemistry. I supply it as a research and industrial intermediate for carbon–carbon bond-forming reactions, especially Suzuki–Miyaura coupling. Its molecular formula is C6H6BBrO2, and its commonly reported molecular weight is approximately 200.81 g/mol. Buyers should confirm the current specification, analytical data, and Safety Data Sheet (SDS) for every production lot before use.
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4-Bromophenylboronic acid is an aromatic boronic acid containing a bromine substituent in the para position relative to the boronic acid group. The boronic acid functionality can react with suitable electrophilic partners under appropriate catalytic and basic conditions, while the aryl bromide may provide an additional site for further chemical transformation. This combination makes the compound useful when a synthesis requires both a boronic acid handle and a halogenated aromatic structure.
In practical procurement, the product is generally treated as a specialty organic intermediate rather than a finished active ingredient. Its suitability depends on factors such as purity, water content, residual solvents, particle form, packaging, and stability during storage. Because reaction performance can vary with process conditions, I recommend reviewing the intended reaction route before selecting a commercial grade.
The best-known use of 4-bromophenylboronic acid is as a boron-containing coupling partner in Suzuki–Miyaura reactions. In this reaction family, the arylboronic acid can couple with an appropriate aryl or vinyl halide to form a new carbon–carbon bond. The exact yield and selectivity depend on the catalyst, base, solvent, temperature, reaction time, substrate structure, and work-up procedure, so I do not treat a general product specification as a guarantee of process yield.
The para-bromo substituent provides a second functional handle for planned downstream chemistry. Depending on the route, chemists may use selective coupling, further derivatization, or sequential reactions to construct more complex biaryl, heteroaryl, pharmaceutical, agrochemical, or materials-related intermediates. The compound is therefore valuable in route development when positional control and subsequent functionalization are important.
Research organizations may use this material for medicinal chemistry libraries, method development, reaction screening, and small-scale synthesis. Industrial users may purchase it for pilot work or as a raw material in a larger multi-step process. For scale-up, I recommend evaluating not only assay but also lot-to-lot consistency, filtration behavior, packaging integrity, and delivery reliability.
4-Bromophenylboronic acid can be considered for several application scenarios in synthetic chemistry. These include preparation of substituted biaryl compounds, development of aromatic intermediates, discovery chemistry, and manufacturing routes that require a para-brominated phenyl unit. It may also be selected for custom synthesis where the bromine atom is retained for a later transformation.
These applications are route-dependent and should be validated by the user’s own laboratory or process team. I recommend starting with a documented small-scale evaluation before committing to larger quantities. The most useful qualification data usually include an assay method, chromatographic purity, water result where relevant, and representative spectral information.
Commercial options may differ by purity target, intended use, packaging configuration, and documentation package. A research-grade material may be suitable for screening, while a process-oriented buyer may require tighter control of impurities and more consistent batch records. The correct choice depends on the sensitivity of the customer’s reaction and the consequences of variation in the final process.
| Material consideration | Why it matters | Buyer action |
|---|---|---|
| Assay and purity | Impurities may influence conversion, selectivity, or purification. | Request the specification and recent COA. |
| Water content | Moisture can affect sensitive reagents and reaction reproducibility. | Confirm whether Karl Fischer or another method is available. |
| Particle form | Particle size and flow may influence charging and dissolution. | Discuss handling needs for laboratory or plant use. |
| Packaging | Appropriate packaging helps protect the material during storage and transport. | Match the container to quantity, handling, and shipping requirements. |
The identity should be confirmed as 4-bromophenylboronic acid with CAS 5467-74-3, molecular formula C6H6BBrO2, and molecular weight approximately 200.81 g/mol. Buyers should also review appearance, assay, related substances, water content, residual solvents, and the analytical methods used for release testing. If the material is intended for a regulated or tightly controlled process, the documentation requirements should be agreed before the purchase order is issued.
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The product is commonly handled as a solid organic chemical, but the exact appearance, color, and physical behavior should be taken from the supplier’s current lot documentation rather than assumed. Melting behavior, solubility, and stability can be influenced by measurement method, sample history, solvent system, and storage conditions. For this reason, I provide or request lot-specific information whenever a customer needs more than a general product description.
4-Bromophenylboronic acid should be handled as a laboratory or industrial chemical with appropriate controls. I recommend reading the current SDS before opening the package, using suitable gloves and eye protection, minimizing dust generation, and working with adequate ventilation or local exhaust. The precise hazard classification depends on the applicable regulatory framework and the supplier’s assessment, so buyers should not rely on an informal summary in place of the official SDS.
The material should remain in its original, correctly labeled container and be stored according to the supplier’s SDS and product instructions. A dry, cool, well-ventilated storage location away from incompatible materials is a conservative starting point, but the final conditions should follow the validated product documentation. I also recommend keeping containers closed when not in use and checking for package damage or unexpected changes in appearance before use.
During transport, packaging should be selected according to the quantity, destination, and applicable chemical shipping requirements. The SDS, label, transport classification, and customs documentation should be reviewed before dispatch. If a customer operates across borders, I can help coordinate the information needed for a more efficient export review, subject to the destination country’s rules.
I suggest evaluating a supplier on more than price alone. A dependable sourcing decision should consider identity confirmation, batch consistency, analytical documentation, packaging, lead-time transparency, export experience, and technical communication. A low unit price may not be advantageous if unclear specifications create delays in qualification or downstream purification.
For planning purposes, buyers should provide an expected order size and delivery destination as early as possible. Laboratory quantities, pilot quantities, and commercial quantities may require different packaging and production arrangements. I avoid promising a fixed lead time without checking stock status, batch availability, testing requirements, and the customer’s documentation needs.
At Maison Chemical, I support customers sourcing 4-bromophenylboronic acid CAS 5467-74-3 for research, development, and manufacturing-related applications. My role is to align the requested identity and specification with a practical supply plan, including quantity, packaging, documentation, and delivery requirements. Where a customer needs a particular purity range or analytical format, I recommend confirming those details before quotation.
I can also help buyers compare sample orders with repeat supply, identify the information needed for internal qualification, and coordinate questions related to export documentation. I do not present a generic specification as a substitute for lot-specific evidence. Instead, I encourage customers to review the available COA, SDS, and technical details against their own quality procedures.
4-Bromophenylboronic acid CAS 5467-74-3 is a versatile organic intermediate for carbon–carbon bond formation and multi-step aromatic synthesis. Its value comes from the combination of a reactive boronic acid group and a para-brominated phenyl structure, but actual performance depends on the reaction system and material quality. The most responsible purchasing decision is based on verified identity, lot-specific analytical data, appropriate safety documentation, and a supply plan matched to the intended scale.
If you are evaluating this product, I recommend sending your target quantity, required purity, application, destination, packaging preference, and documentation requirements to Maison Chemical. I can then help clarify the suitable specification, available supply route, and next steps for sampling or quotation. This approach gives your technical and purchasing teams a clearer basis for qualification before regular procurement.
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