4-(Hydroxymethyl)phenylboronic acid, identified by CAS 59016-93-2, is an aromatic boronic acid intermediate that combines a boronic acid group with a para-hydroxymethyl substituent. Its molecular formula is commonly represented as C7H9BO3, with a calculated molecular weight of approximately 151.96 g/mol. I supply this compound for research, process development, medicinal chemistry, and custom synthesis programs, subject to project-specific specifications and documentation. Buyers should confirm identity, assay, water content, residual solvents, packaging, and delivery requirements before placing a production order.
If you are looking for more details, kindly visit our website.
This guide is intended for procurement teams, research chemists, pharmaceutical development groups, agrochemical laboratories, and chemical manufacturers evaluating 4-(Hydroxymethyl)phenylboronic acid. It is also useful for buyers comparing suppliers for gram-scale screening, kilogram-scale process development, or recurring intermediate supply. The focus is practical: what the material is, how its functional groups are used, what specifications matter, and how to evaluate a reliable supplier.
Because boronic acids can show batch-to-batch differences in hydration, purity, and physical form, a catalog name alone is not enough for purchasing decisions. I recommend reviewing the current certificate of analysis, analytical method, packaging format, and storage guidance for each proposed batch. For regulated or scale-sensitive work, buyers should also align the specification with their internal quality and change-control procedures.
4-(Hydroxymethyl)phenylboronic acid contains two chemically useful handles on the same benzene ring. The boronic acid group, written as –B(OH)2, is commonly used in palladium-catalyzed Suzuki–Miyaura coupling and related carbon–carbon bond-forming chemistry. The hydroxymethyl group, written as –CH2OH, can provide an additional site for derivatization, protection, oxidation, etherification, esterification, or other downstream transformations.
| Property | Buyer-relevant information |
|---|---|
| Compound | 4-(Hydroxymethyl)phenylboronic acid |
| CAS number | 59016-93-2 |
| Approximate molecular formula | C7H9BO3 |
| Approximate molecular weight | 151.96 g/mol |
| Functional groups | Aryl boronic acid and benzylic alcohol |
The material is generally handled as a specialty organic intermediate rather than as a commodity solvent or bulk reagent. Its exact appearance, water content, assay, and stability can depend on manufacturing route, isolation conditions, particle size, and packaging. I therefore avoid treating a single literature or catalog value as a universal release specification, especially when the product may contain different levels of crystal-bound or adsorbed moisture.
The most direct application is use as an aryl boronic acid partner in cross-coupling chemistry. The boronic acid group can participate in carbon–carbon bond formation with suitable aryl or heteroaryl halides under an appropriate catalyst and reaction system. This makes the compound relevant to the preparation of substituted biaryl structures, building blocks, and exploratory medicinal chemistry libraries.
The para-hydroxymethyl substituent can add useful synthetic flexibility to the resulting product. Depending on the target structure, a chemist may retain the alcohol, protect it before coupling, or convert it in a later step. Actual reaction performance depends on substrate compatibility, catalyst selection, base, solvent, temperature, atmosphere, and work-up conditions, so buyers should validate the compound in their own reaction system rather than assume identical performance across all processes.
This building block may also be considered for multi-step synthesis where both the boronic acid and hydroxymethyl groups contribute to route design. It can support the preparation of functionalized aromatic intermediates for pharmaceutical, agrochemical, materials, and analytical research. In route scouting, its value often comes from combining two orthogonal handles in one relatively small molecule.
For process development, the key question is not only whether the compound reacts, but whether it can be charged, sampled, stored, and isolated consistently. A development team may need to compare free boronic acid material with a protected or alternate boron-containing option if hydrolytic stability, purification, or long-term storage becomes a concern. I can discuss these requirements before quotation so the proposed grade matches the intended chemistry.
Buyers may encounter differences in assay level, physical form, packaging, and analytical documentation rather than fundamentally different chemical identities. For early discovery, a research-grade material with a practical minimum assay may be acceptable if the project includes purification or analytical confirmation. For process work, buyers usually need a defined assay range, impurity profile, moisture limit, residual-solvent control, and reproducible packaging configuration.
| Specification area | Why it matters | What to request |
|---|---|---|
| Identity | Confirms the intended compound and functional groups | HPLC, NMR, MS, or other agreed identity data |
| Assay and purity | Influences reaction charging and impurity burden | Current COA and analytical method |
| Water and residual solvents | Can affect weighing, solubility, and reaction reproducibility | Defined limits using an appropriate method |
| Physical form | Affects handling, sampling, and dissolution | Appearance, particle description, and packaging details |
When a specification is not yet fixed, I recommend starting with a small qualification quantity and agreeing on release tests before scale-up. At least three measurable purchasing points should be clearly defined: the required assay percentage, the maximum permitted water content in percent or ppm, and the requested package size in grams or kilograms. These values should be project-specific rather than copied from an unrelated supplier listing.
If you are looking for more details, kindly visit Maison Chemical.
First, define whether the material is intended for reaction screening, analytical reference work, route development, or manufacturing. A laboratory screening project may prioritize fast availability and flexible pack sizes, while a manufacturing program may prioritize lot consistency, validated analytical methods, and supply continuity. The correct grade is the one that meets the project’s risk profile, not necessarily the one with the lowest quoted price.
Ask for a representative certificate of analysis and confirm which tests are performed on the actual supplied batch. Useful documentation may include assay, chromatographic purity, identity confirmation, water, residual solvents, appearance, and lot information. If the material will enter a controlled development or manufacturing process, discuss change notification, retest or shelf-life policy, deviation handling, and document format before commercial approval.
Price, minimum order quantity, and lead time should be reviewed together because a low unit price may not reduce total procurement cost if the minimum order is too large or delivery is uncertain. For a new inquiry, I normally need the target quantity, destination, desired delivery window, packaging preference, and documentation requirements before confirming a quotation. Stock status and lead time can change by batch and order size, so they should be confirmed in writing for each purchase.
As an aromatic boronic acid containing an alcohol group, the compound should be stored and handled according to the supplier’s current safety data and product instructions. Buyers should minimize unnecessary exposure to moisture, heat, contamination, and repeated container opening unless their internal evaluation supports different conditions. Before use, the receiving laboratory should inspect the package, verify the lot number, and compare the material’s appearance and documentation with the purchase specification.
One common mistake is comparing suppliers only by nominal purity without checking how purity is calculated or which impurities are included. Another is assuming that a quoted lead time represents guaranteed delivery without confirming production status, export documentation, and destination requirements. A third is failing to specify whether the buyer needs free-flowing solid, a particular package size, a defined water limit, or a specific analytical method.
It is also risky to assume that every boronic acid will behave identically in storage or coupling reactions. Boronic acids may be sensitive to the selected solvent, pH, temperature, and work-up conditions, while the hydroxymethyl group may require protection in some synthetic routes. I recommend a small-scale compatibility assessment before committing to a large purchase, particularly when the compound is being introduced into a new process.
At Maison Chemical, I approach 4-(Hydroxymethyl)phenylboronic acid as a specification-led sourcing project rather than a simple product lookup. I can help clarify the intended application, quantity range, purity target, packaging, documentation, and delivery destination before proposing a supply option. This approach helps prevent a mismatch between a research-grade request and a process-grade requirement.
Our support can include product identification, quotation preparation, batch documentation review, packaging coordination, and communication about available supply schedules. Where a standard specification does not fit the process, buyers can describe their required assay, impurity controls, analytical tests, or packaging conditions for technical review. Any proposed specification, availability, and lead time should be confirmed against the current batch and order details before purchase.
4-(Hydroxymethyl)phenylboronic acid CAS 59016-93-2 is a versatile research and process-development building block when a project requires an aryl boronic acid together with a hydroxymethyl substituent. Its suitability depends on the planned reaction, required purity, moisture tolerance, storage expectations, and documentation level. The most reliable buying decision comes from matching the product specification to the actual route and scale.
To begin, prepare your target quantity, intended application, assay requirement, packaging preference, destination, and requested delivery date. Send these details to Maison Chemical so I can review the requirement and provide a project-appropriate quotation and documentation plan. For larger or recurring programs, I also recommend qualifying an initial batch before confirming a longer-term supply arrangement.
For more information, please visit 4-(Hydroxymethyl)phenylboronic acid CAS 59016-93-2.