I use 3'-Amino-2'-hydroxybiphenyl-3-carboxylic Acid, CAS 376592-93-7, as a specialty aromatic building block for research, process development, and pharmaceutical-intermediate programs where an aminophenol, carboxylic acid, and biphenyl framework are required in one molecule. Its listed molecular formula is commonly represented as C13H11NO3, with a calculated molecular weight of approximately 229.23 g/mol. Because public data for this relatively specialized intermediate can vary by supplier and grade, I recommend confirming identity, purity, analytical documentation, and physical specifications before placing a production order.
This guide is intended for pharmaceutical and fine-chemical buyers, medicinal chemistry teams, process chemists, laboratory procurement managers, and distributors evaluating CAS 376592-93-7. It is also useful for companies comparing custom synthesis with catalog or stock-based sourcing. I focus on practical selection questions rather than presenting unverified claims about a finished drug, clinical use, or regulatory status.
For early-stage research, the main priorities are usually identity confirmation, available quantity, delivery timing, and analytical suitability. For scale-up, the evaluation must also include batch consistency, impurity control, packaging, storage, documentation, and the supplier’s ability to repeat the same specification. These requirements can differ substantially between a small laboratory order and a multi-kilogram manufacturing project.
3'-Amino-2'-hydroxybiphenyl-3-carboxylic Acid contains a biphenyl core bearing three important functional groups: an amino group, a phenolic hydroxyl group, and a carboxylic acid group. This combination gives the molecule several possible reaction handles for synthesis planning, including amide formation, salt formation, coupling reactions, and transformations involving the aromatic amino or hydroxyl functionality. Actual reactivity depends on reaction conditions, protection strategy, substrate concentration, and the presence of other functional groups.
The compound should be treated as a functionalized aromatic intermediate rather than as a finished pharmaceutical ingredient. Its reported formula, C13H11NO3, corresponds to approximately 229.23 g/mol, which is useful for calculating reaction equivalents and preparing analytical solutions. However, buyers should use the supplier’s current certificate of analysis and an appropriate structure-confirmation method as the controlling documentation for a purchased lot.
Several characteristics are relevant when evaluating this material, but not every property should be assumed from the chemical name alone. Appearance, assay, water content, residual solvents, elemental impurities, and chromatographic impurity profile can be affected by the manufacturing route and purification process. I therefore recommend separating theoretical identity information from lot-specific release data.
| Evaluation item | Buyer relevance | Recommended confirmation |
|---|---|---|
| CAS number | Confirms the intended commercial identity | Check CAS 376592-93-7 against the quotation, label, and COA |
| Molecular formula | Supports stoichiometric calculations | Compare the supplier’s specification with C13H11NO3 |
| Approximate molecular weight | Supports weighing and reaction planning | Use approximately 229.23 g/mol unless the approved specification states otherwise |
| Assay and purity | Influences reaction performance and impurity burden | Request the analytical method, result, and acceptance limit |
| Water and residual solvents | May affect sensitive reactions and storage stability | Request Karl Fischer and residual-solvent data where applicable |
Do not rely on a melting point, solubility value, color description, or storage recommendation copied from a general database without checking the specific grade. These values may depend on solid form, hydration, residual solvent, particle size, and analytical method. For a regulated or scale-up project, I would request a representative COA and, where necessary, supporting spectra such as NMR, FTIR, or mass spectrometry.
The compound may be considered when a project requires a substituted biphenyl scaffold with both amino and carboxylic acid functionality. The carboxylic acid can support downstream amide-coupling strategies, while the amino and hydroxyl groups may participate in additional derivatization or require temporary protection. Whether it is suitable for a specific target depends on the planned route and the required substitution pattern.
In process chemistry, buyers typically evaluate more than nominal purity. They may need consistent impurity profiles, controlled water content, reproducible physical handling, and a supply route that can support multiple batches. A supplier should be able to discuss available batch sizes, packaging, lead-time assumptions, and whether the material is produced to a fixed specification or supplied as a research-grade product.
For route scouting, a smaller quantity can help establish reaction compatibility before committing to a larger purchase. I recommend checking whether the material is supplied as the free acid and whether any salt, solvate, hydrate, or protected derivative is available when that form better suits the process. The correct form should be selected according to the reaction design rather than price alone.
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First, state whether the material is for analytical research, medicinal chemistry, process development, or commercial intermediate production. The intended use determines the appropriate purity target, documentation package, packaging format, and quality-control depth. It also helps the supplier recommend a realistic quantity and delivery plan.
Match the product name, CAS number, molecular formula, molecular weight, and structural drawing. Ask whether the quoted material is the free acid or another chemical form, and confirm whether the label and COA use the same identity. This step reduces the risk of ordering a positional isomer or a material with an uncommunicated salt or solvate form.
At minimum, request a COA showing batch number, assay or purity result, test method, appearance, and relevant impurity information. For a demanding program, ask whether NMR, LC-MS, HPLC, water, residual-solvent, or elemental-impurity data can be provided. The exact package should reflect the risk of the application and the quality agreement between buyer and supplier.
Confirm the minimum order quantity, available stock, production lead time, packaging, shipping conditions, and quotation validity. A low unit price may not be commercially attractive if the minimum order is excessive or the lead time does not fit the project schedule. I also recommend asking whether repeat batches can be manufactured against the same specification.
Pricing for a specialized aromatic intermediate is influenced by quantity, purity requirement, analytical testing, packaging, route complexity, and whether the supplier has material in stock. I avoid presenting a universal price because quotations can change with raw-material availability and project specifications. Buyers should request a tiered quotation for laboratory, development, and production quantities where possible.
MOQ is equally important. A small research order may be available from existing inventory, while a larger order may require production scheduling or custom synthesis. Lead time should be confirmed in writing and separated into stock preparation, quality release, and transportation time so that the purchasing team has a more realistic delivery expectation.
Maison Chemical supports B2B buyers by discussing product identity, quantity requirements, documentation needs, and delivery expectations before quotation. Depending on the project, I can help organize a request for specification review, sample evaluation, or larger-scale supply discussion. Availability, MOQ, lead time, and analytical documentation should be confirmed for each individual inquiry rather than assumed from a general product listing.
In direct answer to the sourcing question, CAS 376592-93-7 can be evaluated as a specialized aromatic pharmaceutical intermediate for research and synthesis programs requiring a substituted biphenyl structure with multiple functional groups. The most reliable purchasing decision comes from combining structure confirmation with lot-specific analytical data and a clear understanding of the intended application. General database information is useful for initial planning, but it should not replace the supplier’s current specification and COA.
As a next step, prepare your target quantity, required purity, application, delivery destination, preferred packaging, and documentation requirements. Send these details to Maison Chemical for a focused B2B quotation and technical review. We can then clarify whether an available grade, a larger production batch, or a custom supply arrangement is the most appropriate route for your project.
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