Procaine: Uses, Interactions, Mechanism of Action

22 Mar.,2024


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A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016). Procaine has also been investigated as an oral entry inhibitor in treatment-experienced HIV patients 2 .

Procaine is a local anesthetic used for anesthesia, peripheral nerve block, and spinal nerve block.

Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose FormUsed in combination to treatOtalgiaCombination Product in combination with: Antipyrine (DB01435)•••••••••••••••••••• • •••••Create Account
Contraindications & Blackbox Warnings

Procaine is an anesthetic agent indicated for production of local or regional anesthesia, particularly for oral surgery. Procaine (like cocaine) has the advantage of constricting blood vessels which reduces bleeding, unlike other local anesthetics like lidocaine. Procaine is an ester anesthetic. It is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-aminobenzoic acid (PABA), which is then excreted by the kidneys into the urine.

Mechanism of action

Not Available

Volume of distribution

Not Available

Protein binding

Not Available


Hydrolysis by plasma esterases to PABA

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  • Procaine

    • N,N-diethyl-2-aminoethanol + para-aminobenzoic acid
Route of elimination

With normal kidney function, the drug is excreted rapidly by tubular excretion.


7.7 minutes


Not Available

Adverse Effects

Not Available

PathwayCategoryProcaine Action PathwayDrug action
Pharmacogenomic Effects/ADRs

Not Available

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