Opioid testing is used to detect evidence of opioid use or misuse. Opioid use identifies the consumption of a class of drugs that are chemically similar to psychoactive agents found in opium. Opioid misuse is used when consumption of these drugs does not match a drug schedule prescribed by a physician to that individual.. Testing for the use and misuse of opioids may be performed for a variety of purposes:
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If you are prescribed opioids for pain, opioid testing allows doctors to monitor for opioid misuse. Opioid misuse includes taking opioids prescribed for another person, taking a larger dose than prescribed, or using an opioid in a way that differs from what is recommended by a doctor, such as snorting or injecting the drug. Monitoring you can help doctors prevent or treat opioid misuse before it develops into an addiction.
Opioid testing can not detect current intoxication or an opioid addiction.
Opioid testing detects the presence of opioids or opioid metabolites in a test sample. Opioid metabolites are substances created when the body is processing and breaking down an opioid. Opioids include both natural and manufactured substances:
Any individual opioid test may not detect all opioids and their metabolites. The types of opioids included in an opioid test varies by medical facility, laboratory, and geographical region. A routine drug screening panel often detects only natural opioids like heroin, morphine, and codeine.
While opioid tests can be ordered on their own, testing is often conducted as part of a broad screening panel. A drug screening panel, such as a 10-panel drug test, may be used to find evidence of a variety of illegal and prescription drugs. If a patient tests positive on an initial drug screening panel, results may be confirmed by a second, more specific test.
Common drug screening panels may not detect widely-used synthetic and semi-synthetic opioids, such as tramadol, methadone, and fentanyl. Testing for these opioids often requires a more extensive panel or a more targeted drug test. For example, the Department of Defense uses an expanded drug panel that includes several semi-synthetic opioids.
Opioids and their metabolites can only be detected in the body for a limited amount of time after use, called the detection window. This varies based on many factors, including the type of opioid used, the amount and frequency of use, the type of test sample and factors specific to the patient such as body weight, ability to process the drug, nutrition and other medications.. The detection window can also vary based on the cutoff values used by an individual laboratory to determine a positive result. The table below provides examples of detection windows for a urine sample:
URINE DETECTION WINDOWS AFTER OPIOID USE OPIOID AND EXAMPLE TRADE NAMES ESTIMATED DETECTION WINDOW Buprenorphine (Buprenex, Suboxone) Up to 14 days Codeine Up to 3 days Fentanyl (Duragesic, Fentora) Up to 3 days Heroin Less than 1 day Hydrocodone (Lorcet, Vicodin) Up to 3 days Hydromorphone (Dilaudid, Exalgo) Up to 3 days Meperidine (Demerol, Mepergan) Up to 4 days Methadone (Dolophine, Methadose) Up to 14 days Morphine (Avinza, Duramorph) Up to 3 days Oxycodone (Oxycontin, Percocet) Up to 3 days Oxymorphone (Numorphan, Opana) Up to 3 days Propoxyphene (Darvon, Darvocet) Up to 4 days Tapentadol (Nucynta) Up to 3 days Tramadol (Ultram) Up to 4 daysThe following table provides examples of detection windows in other types of test samples:
OTHER ESTIMATED DETECTION WINDOWS OPIOID HAIR SALIVA SWEAT Codeine Up to 90 days Up to 36 hours Up to 14 days Morphine Up to 90 days Up to 36 hours Up to 14 days Heroin Up to 90 days Up to 36 hours Up to 14 daysOpioid testing may be used in a variety of settings, including monitoring of prescription opioid use, within a substance use treatment program, and during pre-employment testing. Drug testing requirements are impacted by laws on the federal, state, and local levels. Drug-free policies that require regular drug testing may be implemented in both federal and non-federal workplaces.
Your doctor might ask you to get an opioid test if you are prescribed the medication because of its highly addictive potential. Even if the drug itself is legal, its use may be controlled and so testing can be a precautionary measure.
Get TestedOpioid testing can be performed in a doctor’s office, laboratory, or other medical facility. Test samples can also be obtained on-site at a workplace or other location requiring drug testing. Often, opioid tests can be ordered by your doctor or by an administrator of the program that requires drug testing.
You can buy a drug panel test online and visit the participating lab to get tested for opioids. For example, a 9-panel drug test can test for amphetamines, barbiturates, benzodiazepines, cannabinoid, cocaine, methadone, opiates, phencyclidine (PCP), and propoxyphene. Your doctor does not have to order this test.
At-home drug tests are available to screen for opioid use. At-home opioid testing can be performed on a sample of hair, saliva, or urine. At-home saliva and urine drug tests allow you to conduct a rapid drug screening with results provided quickly in your own home, and you do not need a doctor’s order. At-home hair follicle testing involves collecting a hair sample at home before sending the sample to a laboratory for testing.
Rapid drug tests performed at-home are a type of initial drug screening. Positive results on drug screening tests require confirmation testing.
Aside from testing in a health care professional’s office, you can also order a drug panel test online and visit the participating lab. Keep in mind, online and at-home opioid tests are not a substitute for drug testing conducted by a doctor or other health care professional.
If you purchase an over-the-counter drug test panel that includes screening for opioids, you’ll pay out of pocket and the cost can range from about $10 to $25. You can also order a drug panel test online and visit the participating lab for testing. The cost can range from $109 to $129, depending on how extensive the screening is.
Aside from self-pay, the cost of opioid testing might be covered by your health insurance provider, employer, or the organization requesting the test. If your doctor orders the test, the health care provider pays for it or you might be responsible, in which case you can submit it to insurance. Keep in mind, you might be billed for copays and deductibles.
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Get TestedFor laboratory-based testing, an initial drug screen is usually performed on a clean catch urine sample, which prevents germs from contaminating the sample. You can get tested for opioids in a lab, medical facility, or other testing site and the process can vary based on the sample required. For example, saliva, sweat, and hair samples are another way to test for drugs including opioids.
The process of collecting urine can vary based on the reason for drug testing and the requirements of the testing location. Before a urine drug test, talk to your health care provider about what type of collection will be performed.
There are several ways testing locations prevent urine sample tampering. Some monitor you during the collection, others might require a technician to check the restroom before you enter.
Be sure to talk to your doctor or employer about medications you take because some over-the-counter and prescription drugs can affect opioid test results – and the same is true with some foods like poppy seeds. Do not eat them within three days of a urine test.
There are no other preparations necessary when collecting samples of blood, heair, saliva, or sweat.
Collecting a clean catch urine sample involves several steps. You’ll wash your hands thoroughly with soap and water and clean the area thoroughly with sterile wipes in the testing kit. Then, urinate into the toilet before stopping the flow of urine and moving the collection container a few inches from the urine stream. Fill the container about halfway. Once the urine sample is collected, you can move the collection container aside and finish urinating into the toilet.
The process of collecting other test samples depends on the type of sample needed:
There is very little risk during sample collection, although some people having blood drawn might feel some pinching pain and experience temporary bruising where the needle is inserted. Samples used for drug testing can typically be obtained in less than 5 minutes.
If you’re using an at-home test kit, keep in mind the instructions vary. Be sure to read through the steps carefully before obtaining a sample.
After collecting a clean catch urine sample, simply close the sample container and return it to a staff member at the testing facility, or follow the instructions in the test kit to send to a lab. The staff member may measure and record the temperature of the sample and secure it in tamper-proof packaging before sending it for analysis. Other test samples obtained by a health care professional require nothing additional. There are no restrictions after testing.
Get TestedResults from an opioid test are often available within a few hours to a few business days. Depending on how and where you take the test, you might receive results by a phone call from your doctor, on a secure patient portal, or electronic health record.
Keep in mind, drug screening tests are interpreted differently than laboratory-based testing that confirms initial screening results. So, if you are using an at-home test kit, you might very well need follow-up testing to confirm results.
The cutoff value for an opioid test means the minimum level of opioid or opioid metabolite in a sample that is considered to be a positive result. Cutoff values for opioid testing are not universal and depend on the laboratory or agency conducting the test. As one example, in federal drug-free workplace programs that test for morphine and codeine, the cutoff for both an initial test and for confirmation testing is 2000 ng/mL.
Negative results on an opioid test indicate that the opioids or metabolites measured were not detected in the test sample. This result may indicate that you have not used opioids, that opioid use was outside of the test’s detection window, or that the level of opioid or its metabolite was below the cutoff level for a positive test result.
Positive results on an opioid test indicate that opioid or metabolites were detected in the test sample. If the initial test was a drug screening test, a positive result requires additional confirmation testing that is conducted in a laboratory.
Keep open lines of communication with your health care provider, and don’t hesitate to ask these important questions about opioid testing, the purpose, and how results are interpreted.
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